Heritability and Stability of Resting Blood Pressure in Australian Twins
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Key result
Genetic factors significantly contributed to the variation in resting blood pressure (SBP heritability 19%-56%, DBP heritability 37%-52%), with blood pressure tracking over time explained by the same set of stable genetic factors.
Population
1,895 Australian twins participating in three different studies, age range 18-86 years.
Design
Cohort
Follow-up
average 12 years
Authors
Discussion
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Implication
Should not yet change hypertension practice; supports stable genetic factors in adult BP tracking.
Study Design
Type
Observational (n=1,895)
Structured PICO
P
Population
1,895 Australian twins (368 monozygotic and 335 dizygotic pairs) aged 18 to 86 years, followed across three studies over an average of 12 years to assess the heritability and stability of resting blood pressure.
O
Outcome
Heritability and tracking of resting systolic (SBP) and diastolic blood pressure (DBP)surrogate
Main Result
Effect estimate: SBP h2 = 19%-56%, DBP h2 = 37%-52%
Stable genetic factors influence resting blood pressure across the first part of the adult lifespan, with no evidence of new genetic factors emerging over time.
Limitations
- Low sample size in Study 2 may have led to sampling variation and an artificially low monozygotic correlation (19%) for systolic blood pressure.
- Antihypertensive medication use required statistical correction by adding constant values to measured blood pressures.
- Low sample size in Study 2 leading to potential sampling variation and low MZ correlation
Cite This Study
Hottenga et al. (2006) conducted an observational in Blood pressure variation (n=1,895). Genetic and environmental factors was evaluated on Heritability (h2) of resting systolic and diastolic blood pressure (SBP h2 = 19%-56%, DBP h2 = 37%-52%). Genetic factors significantly contributed to the variation in resting blood pressure (SBP heritability 19%-56%, DBP heritability 37%-52%), with blood pressure tracking over time explained by the same set of stable genetic factors.
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