Key result
Acute shunt occlusion in patients with cirrhosis significantly reduced unilateral renal blood flow by 43.5% (from 289 to 155; p < 0.001), supporting the existence of a hepatorenal reflex.
Why the study?
Does acute increase in portal pressure via shunt occlusion reduce renal blood flow in patients with cirrhosis?
Population
20 patients with cirrhosis and transjugular intrahepatic portosystemic stent-shunts
Comparison
Shunt occlusion during routine portography vs Before shunt occlusion (baseline)
Design
Other
Follow-up
Acute (during routine portography)
Authors
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Portal pressure elevation may reduce renal blood flow via hepatorenal reflex; hypothesis-generating for interventions in cirrhosis.
Does acute increase in portal pressure via shunt occlusion reduce renal blood flow in patients with cirrhosis?
Effect estimate: -43.5%
Absolute Event Rate: 155% vs 289%
p-value: p=< 0.001
Acute increases in portal pressure via shunt occlusion significantly reduce renal blood flow, suggesting the existence of a hepatorenal reflex in humans.
Jalan et al. (1997) studied Cirrhosis (n=20). Shunt occlusion vs. Before shunt occlusion was evaluated on Unilateral renal blood flow (RBF) (-43.5%, p=< 0.001). Acute shunt occlusion in patients with cirrhosis significantly reduced unilateral renal blood flow by 43.5% (from 289 to 155; p < 0.001), supporting the existence of a hepatorenal reflex.
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