Key result
Renal-portal shunting normalizes BP in dogs with renovascular hypertension by increasing hepatic renin metabolism.
Why the study?
The role of the liver in the metabolism of renin and its impact on blood pressure in renovascular hypertension was evaluated.
Does a renal-portal shunt reduce plasma renin activity and blood pressure in dogs with experimental renovascular hypertension?
Does a renal-portal shunt reduce plasma renin activity and blood pressure in dogs with experimental renovascular hypertension?
Directing hyper-reninemic renal blood to the liver via a renal-portal shunt normalizes renin levels and blood pressure in a canine model of renovascular hypertension.
Renal-portal shunting normalizes renin and BP in canine renovascular hypertension; hypothesis-generating, requires clinical validation before any human application.
The role of the liver in the metabolism of renin was evaluated in dogs with high plasma renin and hypertension due to experimental bilateral renal artery stenosis. Ten adult dogs were studied in three consecutive phases: (1) basal conditions, (2) with bilateral ischemic kidneys, and (3) after derivation of renal vein blood into the portal system. Secretion, total clearance, hepatic clearance, and hapatic extraction of renin were estimated in each phase by measuring plasma renin activity (PRA) in blood collected simultaneously from arteries, inferior vena cava, vena porta, hepatic and renal veins, and by determining renal and hepatic blood flow. Blood pressure was measured by intra-arterial catheterization. The results demonstrated an increase in the hepatic metabolism of renin when the hyper-reninemic patterns of renal blood directly perfused the liver. Under these conditions, hepatic and circulating renin fell to basal values and blood pressure returned to normal.
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Cugini et al. (1980) studied Experimental renovascular hypertension (n=10). Derivation of renal vein blood into the portal system (Renal-Portal Shunt) vs. Basal conditions and bilateral ischemic kidneys (within-subject phases) was evaluated on Hepatic metabolism of renin, plasma renin activity, and blood pressure. Derivation of renal vein blood into the portal system in dogs with experimental renovascular hypertension increased hepatic renin metabolism, returning circulating renin and blood pressure to normal.
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