Key result
A 51-year-old female survivor of childhood Wilms tumor presented with stage 4 liver angiosarcoma, highlighting the potential for secondary liver tumors in this population.
Case Report (n=1)
Highlights a rare case of stage 4 liver angiosarcoma in an adult survivor of childhood Wilms tumor.
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May warrant vigilance for secondary liver tumors in Wilms survivors; hypothesis-generating for surveillance strategies.
Hepatic angiosarcoma is a rare, highly aggressive mesenchymal liver malignancy with poor prognosis that stems from the endothelial cells that line the walls of blood or lymphatic vessels. It is the third most common primary liver malignancy and is most prevalent among older males. It is difficult to diagnose due to various clinical presentations from asymptomatic to abdominal pain, pleural effusion, and liver failure. The diagnosis of liver angiosarcoma is suspected on imaging features and confirmed by histopathological assessment. Primary management is determined based on the stage of tumor from surgery to palliative care such as chemotherapy or tumor transarterial embolization. We report a 51-year-old female who presented with stage 4 liver angiosarcoma and a history of childhood Wilms tumor. We focus on tumor management using radiological modalities and pathological analysis and discuss secondary liver tumors in survivors of childhood Wilms tumor.
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Shayesteh et al. (2020) conducted a case report in Hepatic angiosarcoma and history of childhood Wilms tumor (n=1). History of childhood Wilms tumor was evaluated. A 51-year-old female survivor of childhood Wilms tumor presented with stage 4 liver angiosarcoma, highlighting the potential for secondary liver tumors in this population.
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