Key result
mRNA levels of IGFs, IGFBPs, and receptors for GH, IGFs, and insulin differed significantly among gastrointestinal sites and between days 1 and 5 of life (P < 0.05).
p-value: p=<0.05
May inform models of neonatal GI maturation; leaves open links to clinical outcomes in infants.
Growth hormone (GH), insulin-like growth factors (IGFs) and insulin influence post-natal gastrointestinal development and function. We have measured by real-time PCR the mRNA levels of IGF-1 and -2, IGF-binding proteins (IGFBPs)-2 and -3, and receptors for GH, IGF type-1 and -2, and insulin in esophagus, rumen, fundus, pylorus, duodenum, jejunum, ileum and colon of calves on days 1 and 5 of life. Levels of mRNA of measured traits were different (P < 0.05) at different gastrointestinal sites. Furthermore, mRNA levels of IGFs, IGFBPs and of receptors for GH and IGF type-1 and -2 and insulin differed (P < 0.05) on days 1 and 5. Differences in mRNA abundance of IGFs, IGFBPs and of receptors for GH, IGFs, and insulin among gastrointestinal sites on days 1 and 5 of life suggest site-specific functional importance and demonstrate that changes are the consequence of ontogenetic development and/or due to feeding.
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Ontsouka et al. (2004) studied Neonatal calves. Age (Day 1 vs Day 5) and Gastrointestinal site was evaluated on mRNA levels of IGF-1 and -2, IGFBPs-2 and -3, and receptors for GH, IGF type-1 and -2, and insulin (p=<0.05). mRNA levels of IGFs, IGFBPs, and receptors for GH, IGFs, and insulin differed significantly among gastrointestinal sites and between days 1 and 5 of life (P < 0.05).
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