Key result
NIDDM patients with albuminuria had significantly higher 24-h urinary ET-1-LI excretion compared to normal controls (174.4 vs 111.8 ng/day, P<0.01).
Why the study?
Is urinary endothelin-1-like immunoreactivity excretion elevated in NIDDM patients with albuminuria?
Cross-Sectional (n=113)
Is urinary endothelin-1-like immunoreactivity excretion elevated in NIDDM patients with albuminuria?
Urinary endothelin-1 excretion is elevated in NIDDM patients with albuminuria, suggesting a potential pathogenetic role in diabetic nephropathy.
Answers are grounded in this paper and cite their sources.
Elevated urinary ET-1 in albuminuric NIDDM may mark nephropathy risk; cross-sectional data leave causality and clinical utility unresolved.
OBJECTIVE: To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS: Urinary ET-1-LI substance was determined by radioimmunoassay in 45 normoalbuminuric and 28 albuminuric NIDDM patients. RESULTS: The mean amounts of 24-h ET-1-LI excretion in NIDDM patients with normoalbuminuria and albuminuria were 154.9 +/- 13.5 and 174.4 +/- 12.9 ng/day, respectively. The latter was significantly higher than that of the 40 normal control subjects (111.8 +/- 7.9 ng/day, P < 0.01). CONCLUSIONS: The increase in urinary ET-1-LI substance excretion in patients with albuminuria suggests that ET-1 may be a pathogenetic factor in diabetic nephropathy.
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Lee et al. (1994) conducted a cross-sectional in Non-insulin-dependent diabetes mellitus (NIDDM) (n=113). NIDDM with albuminuria vs. Normal control subjects was evaluated on 24-h urinary ET-1-LI excretion (ng/day) (p=<0.01). NIDDM patients with albuminuria had significantly higher 24-h urinary ET-1-LI excretion compared to normal controls (174.4 vs 111.8 ng/day, P<0.01).
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