Key result
Elevated maternal serum uric acid levels were significantly associated with a lower requirement for vasopressors to treat post-spinal hypotension in preeclamptic patients undergoing cesarean delivery.
Why the study?
Serum uric acid is associated with impaired vascular relaxation and predicts hypertension, but its association with post-spinal hypotension in preeclamptic parturients required evaluation.
Is elevated serum uric acid associated with reduced post-spinal hypotension and vasopressor requirement in preeclamptic patients undergoing cesarean section?
Observational (n=204)
No
Is elevated serum uric acid associated with reduced post-spinal hypotension and vasopressor requirement in preeclamptic patients undergoing cesarean section?
Elevated serum uric acid levels in preeclamptic patients are inversely associated with the development of post-spinal hypotension and the need for vasopressors during cesarean delivery.
May support uric acid monitoring for hypotension risk in PIH cesarean; hypothesis-generating, needs prospective confirmation before practice change.
Serum Uric acid (UA) is a marker of oxidative stress in preeclampsia. Hyperuricemia has been shown to be associated with impaired vascular relaxation in some retrospective studies. Elevated uric acid is also an independent predictor of hypertension. This study is designed to study the association between elevated serum uric acid levels and post spinal hypotension in pregnancy induced hypertension patients undergoing elective caesarean delivery under spinal anesthesia, as measured by requirement of vasopressors. Materials and Methods: 204 patients with pregnancy induced hypertension scheduled for elective caesarean section under spinal anesthesia were included in the study. Demographic data, anesthetic management and peripartum course were recorded. Serum uric levels were measured on arrival to operation theatre. Doses of vasopressor agents required after spinal anesthesia was recorded. The association between serum uric acid level and requirement of vasopressor was studied. Data was analysed using students t test and chisquare test. P-value<0.05 was considered significant. Results and Observations: Requirement of vasopressors was lower in patients with high serum uric acid levels than those with lower serum uric acid levels. Results were similar with both phenylephrine and ephedrine. The difference in vasopressor requirement was statistically significant.(p-value<0.05) Conclusion: Elevated serum uric acid levels are inversely related to development of post spinal hypotension and requirement of vasopressors in preeclamptic patients undergoing cesarean section under spinal anesthesia.
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Tantry Tariq Gani (2020) conducted an observational in Pregnancy induced hypertension (n=204). Elevated serum uric acid vs. Lower serum uric acid was evaluated on Requirement of vasopressors for post-spinal hypotension (p=<0.001). Elevated maternal serum uric acid levels were significantly associated with a lower requirement for vasopressors to treat post-spinal hypotension in preeclamptic patients undergoing cesarean delivery.
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