Key result
Prophylactic bolus doses of phenylephrine 75 mcg and 100 mcg reduced the incidence of spinal-induced hypotension compared to control (25% and 17.5% vs 70%, P<0.001).
Why the study?
Hypotension following spinal anesthesia during cesarean delivery causes adverse maternal and fetal effects, and the influence of different prophylactic phenylephrine doses needed evaluation.
Does prophylactic phenylephrine reduce the incidence of spinal-induced hypotension in parturients undergoing cesarean section under spinal anesthesia?
Population
120 ASA grade I and II parturients undergoing cesarean section under spinal anesthesia
Comparison
Group P0 vs group P75 vs group P100
Design
Prospective double-blinded randomized study
Authors
Loading...
75 mcg phenylephrine bolus may lower spinal hypotension rates in cesarean delivery; leaves open optimal dosing across diverse populations.
RCT (n=120)
Double-blind
randomized
Does prophylactic phenylephrine reduce the incidence of spinal-induced hypotension in parturients undergoing cesarean section under spinal anesthesia?
Absolute Event Rate: 25% vs 70%
p-value: p=< 0.001
A prophylactic bolus dose of 75 mcg phenylephrine effectively prevents spinal-induced hypotension during cesarean section with fewer side effects than a 100 mcg dose.
Partani et al. (2019) conducted an RCT in cesarean section under spinal anesthesia (n=120). Phenylephrine vs. No phenylephrine (Group P0) was evaluated on incidence of spinal-induced hypotension during cesarean section (p=< 0.001). Prophylactic bolus doses of phenylephrine 75 mcg and 100 mcg reduced the incidence of spinal-induced hypotension compared to control (25% and 17.5% vs 70%, P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: