Key result
A prophylactic IV bolus of 75 mcg phenylephrine was as effective as 100 mcg in preventing spinal-induced hypotension during cesarean section (16.6% vs 16.6%), but caused less bradycardia.
Why the study?
Hypotension occurs in most parturients following spinal anesthesia during Cesarean section, warranting evaluation of different bolus doses of phenylephrine for its prevention.
Does phenylephrine 75 mcg IV bolus compared to 100 mcg IV bolus prevent spinal-induced hypotension in parturients undergoing cesarean section?
Population
120 parturients undergoing cesarean section
Comparison
Phenylephrine 75 mcg IV bolus vs phenylephrine 100 mcg IV bolus
Design
Prospective observational study
Follow-up
20 minutes
Authors
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May support 75 mcg phenylephrine to limit bradycardia in cesarean delivery; leaves open randomized confirmation.
Observational (n=120)
Does phenylephrine 75 mcg IV bolus compared to 100 mcg IV bolus prevent spinal-induced hypotension in parturients undergoing cesarean section?
Absolute Event Rate: 16.6% vs 16.6%
A prophylactic bolus of 75 mcg phenylephrine is as effective as 100 mcg for preventing spinal-induced hypotension during cesarean section, but with a lower risk of bradycardia.
Hiruthick et al. (2021) conducted an observational in Spinal-induced hypotension during cesarean section (n=120). Phenylephrine vs. Phenylephrine 100 mcg IV bolus was evaluated on Hypotension. A prophylactic IV bolus of 75 mcg phenylephrine was as effective as 100 mcg in preventing spinal-induced hypotension during cesarean section (16.6% vs 16.6%), but caused less bradycardia.
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