Key result
Preeclamptic parturients experienced a significantly higher incidence of spinal-induced hypotension (53%) compared to healthy parturients (25%) during cesarean section.
Why the study?
Preeclampsia/eclampsia is the third leading cause of maternal morbidity and mortality, prompting an evaluation of the incidence and severity of spinal-induced hypotension in preeclamptic versus healthy parturients.
Does spinal anesthesia with hyperbaric bupivacaine cause more hypotension in preeclamptic parturients compared to healthy parturients undergoing cesarean section?
Observational (n=60)
Blinded co-investigators
Random selection using a computer-generated random number
No
Does spinal anesthesia with hyperbaric bupivacaine cause more hypotension in preeclamptic parturients compared to healthy parturients undergoing cesarean section?
Absolute Event Rate: 53% vs 25%
p-value: p=<0.001
Spinal-induced hypotension during cesarean section is significantly more frequent and severe in preeclamptic parturients compared to healthy parturients.
May warrant closer monitoring in preeclamptic cesarean patients; leaves open whether technique modifications mitigate risk.
Background: Preeclampsia/eclampsia is the third leading cause of maternal morbidity and mortality. This study aimed to evaluate the incidence and severity of spinal-induced hypotension in preeclamptic and healthy parturients. Material & Methods: A total of 60 pregnant patients undergoing a C-Section with spinal anesthesia were randomly allocated into two groups. Group I: Preeclamptic 0.5%, 2.5cc (12.5mg) Hyperbaric Bupivacaine group: 30 patients. Group II: Normotensive 0.5%, 2.5cc (12.5mg) Hyperbaric Bupivacaine group: 30 patients. The blood pressure values were recorded before spinal anesthesia and 2.5 minutes after a spinal puncture. Results: The mean age of the study group was 25.17+3.61 years (Mean +S.D.) and range is 18-30Years. The BP falls from baseline were significantly greater in the healthy parturients compared to those with preeclampsia (25.8% ± 10.1 vs 18.8% ± 17.0 for SBP, 28.5% ± 8.8 vs 22.5% ± 10.4 for DBP, and 31.2% ± 14.2 vs 18.2% ± 12.6% for MAP, p < 0.05). The incidence rate of hypotension in preeclamptic was 53% compared to 25% in healthy parturients (p < 0.001). Conclusion: The incidence of spinal-induced hypotension associated with patients undergoing C-Section is more in preeclamptic than in healthy parturients.
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Vashishth et al. (2022) conducted an observational in Preeclampsia in parturients undergoing cesarean section (n=60). Preeclampsia vs. Healthy parturients was evaluated on Incidence of spinal-induced hypotension (p=<0.001). Preeclamptic parturients experienced a significantly higher incidence of spinal-induced hypotension (53%) compared to healthy parturients (25%) during cesarean section.
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