Key result
Preeclamptic parturients undergoing cesarean section under spinal anesthesia maintained significantly higher mean arterial pressure up to 150 minutes post-injection compared to normotensive parturients.
Why the study?
Haemodynamic adaptation in pre-eclampsia diverges from normotensive pregnancies and may predispose women to cardiopulmonary complications during pregnancy, delivery, and puerperium.
Does spinal anaesthesia with hyperbaric bupivacaine cause different haemodynamic responses in preeclamptic versus normotensive parturients undergoing cesarean section?
Population
60 parturients aged 18 to 30 years undergoing elective caesarean section
Comparison
Preeclamptic parturients vs normotensive parturients receiving spinal anaesthesia
Design
Randomized comparative study
Follow-up
150 min
Authors
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Supports less hypotension after spinal in preeclampsia; leaves open whether RCTs should alter cesarean anesthesia protocols.
Cohort (n=60)
Single-blind (Investigator blinded)
Sealed envelope method (for selection)
No
Does spinal anaesthesia with hyperbaric bupivacaine cause different haemodynamic responses in preeclamptic versus normotensive parturients undergoing cesarean section?
Absolute Event Rate: 96.5% vs 86.8%
p-value: p=0.001
Spinal anesthesia with hyperbaric bupivacaine maintains higher blood pressures in preeclamptic compared to normotensive parturients, with less hypotension reported.
Manik et al. (2020) conducted a cohort in Preeclampsia in pregnancy (n=60). Preeclampsia vs. Normotensive pregnancy was evaluated on Mean Arterial Pressure (MAP) at 150 minutes (p=0.001). Preeclamptic parturients undergoing cesarean section under spinal anesthesia maintained significantly higher mean arterial pressure up to 150 minutes post-injection compared to normotensive parturients.
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