Key result
Severe pre-eclamptic women require ~68% less phenylephrine during cesarean spinal anesthesia than normotensive women.
Why the study?
Does spinal anesthesia result in different hemodynamic responses and vasopressor requirements in severe pre-eclamptic women compared to normotensive women undergoing cesarean section?
Population
60 parturients above 18 years of age undergoing elective cesarean section, comprising 30 healthy…
Comparison
Spinal anesthesia with 12.5 mg hyperbaric… vs Spinal anesthesia with 12.5 mg hyperbaric…
Design
Cohort
Follow-up
Until completion of surgery
Authors
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May support spinal anesthesia in severe pre-eclampsia; leaves open confirmation by randomized trials.
Cohort (n=60)
Does spinal anesthesia result in different hemodynamic responses and vasopressor requirements in severe pre-eclamptic women compared to normotensive women undergoing cesarean section?
Absolute Event Rate: 48.3% vs 151.1%
p-value: p=< 0.0001
Severe pre-eclamptic women experience less hypotension and require less phenylephrine following spinal anesthesia compared to normotensive women during cesarean section.
Ghosh et al. (2013) conducted a cohort in Severe pre-eclampsia in women undergoing cesarean section (n=60). Severe pre-eclampsia vs. Normotensive was evaluated on Mean phenylephrine requirement (p=< 0.0001). Severe pre-eclamptic women undergoing cesarean section under spinal anesthesia required significantly less phenylephrine (48.3 vs 151.1 µg; P<0.0001) than normotensive women.
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