An Enzyme Inhibitor, Panosialin, Produced by Streptomyces

In the screening of streptomyces culture filtrates for inhibitors of viral sialidase, acid phosphatase and polygalacturonase, a new type of compound was isolated and named panosialin. It had the following ID50 values : 9×10-6 M, 3.8×10-5M and 3.9×10-5M againt sialidase, acid phosphatase and polygalacturonase respectively. In this paper, characters of the panosialin-producing strains and the isolation of panosialin are described. It was found to bind to protein and to have an action similar to that of detergents.