Key result
Addition of activated protein kinase C to human platelet membranes eliminated or largely impaired hormonal inhibition of adenylate cyclase by epinephrine.
Population
Membranes of human platelets
Design
Preclinical
Authors
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May link PKC to impaired platelet cAMP regulation; leaves open effects on hemostasis or antiplatelet responses.
Activated protein kinase C interferes with GTP- and hormone-induced adenylate cyclase inhibition in human platelets, likely by phosphorylating the inhibitory guanine nucleotide-binding regulatory component Ni.
Watanabe et al. (1985) studied this question. phorbol ester-activated, partially purified protein kinase C was evaluated on adenylate cyclase activity and inhibition. Addition of activated protein kinase C to human platelet membranes eliminated or largely impaired hormonal inhibition of adenylate cyclase by epinephrine.
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