March 8, 1999Archives of Internal Medicine
Plasma Insulin Levels and Incidence of Hypertension in African Americans and Whites
Key result
A 1-SD increase in baseline insulin-to-glucose ratio was associated with increased incident hypertension risk in African Americans (OR 2.77; 95% CI 1.48-5.19) and whites (OR 1.69; 95% CI 1.08-2.64).
Why the study?
Do higher plasma insulin levels increase the risk of incident hypertension in African Americans and whites?
Population
377 individuals initially screened for possible participation in the Trials of Hypertension Prevention…
Comparison
Higher baseline plasma insulin and… vs Lower baseline plasma insulin and…
Design
Cohort
Follow-up
7 years
Authors
Discussion
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Member takes
Implication
Should not alter clinical hypertension risk assessment; leaves open whether insulin resistance causes incident hypertension in either group.
Study Design
Type
Cohort (n=377)
Structured PICO
Do higher plasma insulin levels increase the risk of incident hypertension in African Americans and whites?
P
Population
377 African American and white individuals screened for the Trials of Hypertension Prevention, followed for 7 years to assess incident hypertension.
E
Exposure
Higher baseline plasma insulin and insulin-to-glucose ratio
C
Comparator
Lower baseline plasma insulin and insulin-to-glucose ratio
O
Outcome
Incident hypertension (average systolic pressure ≥160 mm Hg and/or diastolic pressure ≥95 mm Hg at a single visit and/or use of antihypertensive medication) over 7 yearshard clinical
Main Result
Odds Ratio: 2.77 (95% CI 1.48–5.19)
Higher baseline plasma insulin levels and insulin-to-glucose ratios are associated with an increased risk of developing hypertension over 7 years in both African American and white populations.
Cite This Study
He et al. (1999) conducted a cohort in Hypertension (n=377). Baseline plasma insulin and insulin-to-glucose ratio was evaluated on Incident hypertension (average systolic pressure ≥160 mm Hg or diastolic ≥95 mm Hg at a single visit and/or use of antihypertensive medication) (OR 2.77 (African Americans), OR 1.69 (whites), 95% CI 1.48-5.19 (African Americans), 1.08-2.64 (whites)). A 1-SD increase in baseline insulin-to-glucose ratio was associated with increased incident hypertension risk in African Americans (OR 2.77; 95% CI 1.48-5.19) and whites (OR 1.69; 95% CI 1.08-2.64).