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August 1, 1992Nucleosides and Nucleotides

Synthesis of Suitably-Protected Phosphoramidites of 2′-Fluoro-2′-Deoxyguanosine and 2′-Amino-2′-Deoxyguanosine for Incorporation Into Oligoribonucleotides

Fritz Benseler David M. Williams Fritz Eckstein

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Abstract

A novel synthesis of 2′-fluoro-2′-deoxyguanosine employing DAST as the fluorinating agent is presented. The preparation of its phosphoramidite as well as that of 2′-amino-2′-deoxyguanosine is also described.

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Benseler et al. (1992) studied this question.

synapsesocial.com/papers/6a93bde004d7c7946bb861b0 https://doi.org/10.1080/07328319208021177

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