Key result
Mean global end-diastolic volume index was independently associated with delayed cerebral ischemia (HR 0.74; 95% CI 0.60-0.93; p=0.008) and pulmonary edema (HR 1.31; 95% CI 1.02-1.71; p=0.03).
Why the study?
Is global end-diastolic volume index associated with delayed cerebral ischemia and pulmonary edema in patients with aneurysmal subarachnoid hemorrhage?
Population
180 patients with aneurysmal subarachnoid hemorrhage
Design
Cohort
Follow-up
14 days
Authors
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May inform fluid targets in aneurysmal subarachnoid hemorrhage; hypothesis-generating and requires randomized confirmation before practice change.
Cohort (n=180)
Yes
Is global end-diastolic volume index associated with delayed cerebral ischemia and pulmonary edema in patients with aneurysmal subarachnoid hemorrhage?
Hazard Ratio: 0.74 (95% CI 0.6–0.93)
p-value: p=0.008
Global end-diastolic volume index is associated with both delayed cerebral ischemia and pulmonary edema after subarachnoid hemorrhage, suggesting a target range for fluid management.
Tagami et al. (2014) conducted a cohort in aneurysmal subarachnoid hemorrhage (n=180). Mean global end-diastolic volume index was evaluated on delayed cerebral ischemia (HR 0.74, 95% CI 0.60-0.93, p=0.008). Mean global end-diastolic volume index was independently associated with delayed cerebral ischemia (HR 0.74; 95% CI 0.60-0.93; p=0.008) and pulmonary edema (HR 1.31; 95% CI 1.02-1.71; p=0.03).
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