Key result
Pregnancy was associated with a significant decrease in augmentation index and increase in heart rate, with a non-significant decreasing trend in central systolic blood pressure.
Why the study?
Only peripheral blood pressure is measured in clinical practice during pregnancy, though central blood pressure is a better predictor of cardiovascular events.
How do central blood pressure, peripheral blood pressure, and augmentation index vary between healthy non-pregnant women and pregnant women across different trimesters?
Cross-Sectional (n=160)
How do central blood pressure, peripheral blood pressure, and augmentation index vary between healthy non-pregnant women and pregnant women across different trimesters?
Pregnancy is associated with significant hemodynamic changes, including a decrease in augmentation index and an increase in heart rate, highlighting the potential utility of central blood pressure monitoring.
AIx declines across trimesters; hypothesis-generating for central hemodynamics monitoring, needs longitudinal validation before clinical consideration.
Pregnancy is associated with alteration in the hemodynamic state. In clinical practice, only peripheral blood pressure is measured; however, central blood pressure is a better predictor of cardiovascular events. We have investigated variations in peripheral blood pressure, central blood pressure, and augmentation index in healthy non-pregnant and pregnant women. This was a cross-sectional study of 107 pregnant women (I trimester n = 19, II trimester n = 39, and III trimester n = 49) and age-matched 53 non-pregnant women (Follicular phase n = 25 and luteal phase n = 28). The augmentation index showed a significant decrease with the progression of pregnancy. Central systolic blood pressure showed a decreasing trend (non-significant) with the progression of pregnancy. Heart rate shows a significant increase from follicular to luteal phase in non-pregnant women, which further increases with the progression of pregnancy. Longitudinal studies involving larger sample sizes might provide some insights into the significance of including central blood pressure and augmentation index for routine checkups in both non-pregnant and pregnant women.
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Priyadarsini et al. (2023) conducted a cross-sectional in Pregnancy (n=160). Pregnancy vs. Non-pregnant state was evaluated on Variations in peripheral blood pressure, central blood pressure, and augmentation index. Pregnancy was associated with a significant decrease in augmentation index and increase in heart rate, with a non-significant decreasing trend in central systolic blood pressure.
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