Why the study?
Does delivery improve central hemodynamic parameters in women with hypertensive disorders of pregnancy?
Does delivery improve central hemodynamic parameters in women with hypertensive disorders of pregnancy?
Delivery significantly improves central hemodynamics (AIx@75 and central PP) in women with hypertensive disorders of pregnancy, suggesting aortic stiffness plays a key role in HDP pathophysiology.
Delivery effects on central hemodynamics may be HDP-specific; leaves open aortic stiffness role and need for prospective validation.
The authors tested the hypothesis that central hemodynamic parameters in women with hypertensive disorders of pregnancy (HDP) change between before and after delivery. A total of 137 pregnant women were studied: 72 with HDP, 42 with chronic hypertension (CH), and 23 with white-coat hypertension (WCH; control group). Aortic augmentation index adjusted by heart rate 75 beats per minute (AIx@75), central pulse pressure (PP), total peripheral resistance (TPR), and cardiac output (CO) before and after delivery were recorded. AIx@75 and central PP were higher in the HDP group than in the control group, but both parameters declined after delivery until they were similar to the controls. AIx@75 and central PP, but not TPR or CO, were significantly decreased after delivery in the HDP group, but no such effects were seen in the other groups. These findings suggest that increased wave reflection caused by the stiffened aorta could be a key factor in the pathophysiology of HDP.
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Fukushima et al. (2015) studied this question.
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