Key result
Hypertensive disorders of pregnancy linked to ~7% greater AIx 1 year postpartum vs uncomplicated pregnancies.
Why the study?
Does a history of hypertensive disorders of pregnancy increase blood pressure and arterial stiffness 1-year postpartum compared to uncomplicated pregnancies?
Cross-Sectional (n=74)
Does a history of hypertensive disorders of pregnancy increase blood pressure and arterial stiffness 1-year postpartum compared to uncomplicated pregnancies?
Mean Difference: 7.3
p-value: p=<.05
Women with a history of hypertensive disorders of pregnancy exhibit signs of reduced endothelial function, specifically a greater augmentation index, at 1 year postpartum.
May indicate need for enhanced postpartum vascular surveillance; leaves open whether targeted interventions improve long-term outcomes.
Hypertensive disorders of pregnancy (HDP) are associated with cardiovascular disease (CVD) later in life. The authors investigated the association of HDP with blood pressure (BP) and arterial stiffness 1-year postpartum. Seventy-four participants, 33 with an HDP and 41 with uncomplicated pregnancies, were examined using applanation tonometry to measure BP, carotid-femoral pulse wave velocity (cfPWV), and augmentation index (AIx). On average, women with HDP had a 9 mm higher systolic BP (P<.01), 0.8 m/s faster cfPWV (P=.09), and 5.4% greater AIx (P=.09) at the 1-year examination. After adjustment for covariates, there was no significant difference in cfPWV between groups, while a 7.3% greater AIx (P<.05) remained. These findings suggest that reduced endothelial function may be detected 1 year after HDP. Large prospective studies are needed to further understand the contribution of arterial stiffness and endothelial dysfunction in the evolution of CVD after these complicated pregnancies.
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Ehrenthal et al. (2014) conducted a cross-sectional in Hypertensive disorders of pregnancy (n=74). Hypertensive disorders of pregnancy vs. Uncomplicated pregnancies was evaluated on Augmentation index (AIx) after adjustment for covariates (MD 7.3%, p=<.05). Hypertensive disorders of pregnancy were associated with a 7.3% greater augmentation index 1 year postpartum compared to uncomplicated pregnancies (P<.05).
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