What question did this study set out to answer?

To evaluate whether noninvasive pulse wave analysis in low-risk normotensive women during the first trimester can detect subclinical arterial stiffness and predict the later development of hypertensive disorders of pregnancy.

October 11, 2018Journal of Hypertension

Arterial stiffness in normal pregnancy at 11–13 weeks of gestation and risk of late-onset hypertensive disorders of pregnancy

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Pregnancy (n=1648). Intervention: Arterial stiffness (pulse wave analysis parameters) vs. Normal arterial stiffness. Primary outcome: Development of hypertensive disorders later in pregnancy (p=<0.0001).

View Full Paper

Ask AI

Bookmark

Key result

First-trimester aortic systolic pressure was significantly higher in women who later developed hypertensive disorders (P<0.0001), predicting hypertension with 72.6% sensitivity and 59.6% specificity.

Why the study?

Does pulse wave analysis in the first trimester predict the development of hypertensive disorders later in pregnancy in normotensive, low-risk women?

Key Points

To evaluate whether noninvasive pulse wave analysis in low-risk normotensive women during the first trimester can detect subclinical arterial stiffness and predict the later development of hypertensive disorders of pregnancy.
Recruited 1,648 normotensive, low-risk pregnant women at 11–12 weeks of gestation during prenatal screening for chromosomal abnormalities.
Assessed radial pressure waveforms via Sphygmocor applanation tonometry in the recumbent position to derive central hemodynamic metrics, including aortic pressures and augmentation index.
First-trimester aortic systolic pressure (P < 0.0001), aortic diastolic pressure (P < 0.0001), aortic mean pressure (P < 0.0001), aortic pulse pressure (P = 0.0140), and augmentation index-75 (P < 0.0001) were significantly higher in women who later developed hypertensive disorders than in those who remained normotensive.
Aortic systolic pressure was the most effective predictor of late-onset hypertensive disorders of pregnancy, demonstrating a sensitivity of 72.6% and a specificity of 59.6%.

Study Design

Type

Observational (n=1,648)

Structured PICO

Does pulse wave analysis in the first trimester predict the development of hypertensive disorders later in pregnancy in normotensive, low-risk women?

Population

1,648 normotensive, low-risk pregnant women evaluated at 11-12 weeks of gestation to assess the correlation between arterial stiffness and the development of hypertensive disorders later in pregnancy.

Exposure

Pulse wave analysis (PWA) using applanation tonometry to measure arterial stiffness parameters (aortic systolic, diastolic, mean, and pulse pressures, augmentation pressure, and augmentation index)

Outcome

Development of hypertensive disorders later in pregnancyhard clinical

Main Result

p-value: p=<0.0001

Pulse wave analysis in the first trimester of pregnancy can detect early increases in arterial stiffness that predict the later development of hypertensive disorders.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support routine screening; leaves open prospective validation of pulse wave analysis for hypertensive disorder prediction.

Cite This Study

Marozio et al. (2018) conducted an observational in Pregnancy (n=1,648). Arterial stiffness (pulse wave analysis parameters) vs. Normal arterial stiffness was evaluated on Development of hypertensive disorders later in pregnancy (p=<0.0001). First-trimester aortic systolic pressure was significantly higher in women who later developed hypertensive disorders (P<0.0001), predicting hypertension with 72.6% sensitivity and 59.6% specificity.

synapsesocial.com/papers/6a9ecf78d4f4c5237ab287a3 https://doi.org/10.1097/hjh.0000000000001971

View Full Paper

Ask AI

Bookmark

Arterial stiffness in normal pregnancy at 11–13 weeks of gestation and risk of late-onset hypertensive disorders of pregnancy

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Arterial stiffness in normal pregnancy at 11–13 weeks of gestation and risk of late-onset hypertensive disorders of pregnancy

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider