Key result
Women who developed pre-eclampsia had significantly increased first-trimester augmentation index (1.13 vs 1.00 MoM, p<0.0001), pulse wave velocity, and central aortic systolic blood pressure.
Why the study?
Are increased central aortic systolic blood pressure and arterial stiffness at 11-13 weeks' gestation associated with the subsequent development of pre-eclampsia or gestational diabetes?
Population
7,526 women with singleton pregnancies at 11+0-13+6 weeks' gestation, including those who later developed…
Design
Cohort
Follow-up
Until delivery (to determine pregnancy outcomes)
Authors
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First-trimester arterial stiffness measures were associated with later pre-eclampsia; hypothesis-generating for early risk stratification pending prospective validation.
Cohort (n=7,526)
Are increased central aortic systolic blood pressure and arterial stiffness at 11-13 weeks' gestation associated with the subsequent development of pre-eclampsia or gestational diabetes?
Absolute Event Rate: 1.13% vs 1%
p-value: p=<0.0001
Increased central aortic systolic blood pressure and arterial stiffness are apparent in the first trimester of pregnancy among women who subsequently develop pre-eclampsia or gestational diabetes.
Khalil et al. (2012) conducted a cohort in Pregnancy (n=7,526). Development of pre-eclampsia or gestational diabetes vs. Unaffected controls was evaluated on Augmentation index (AIx-75) in women who developed pre-eclampsia (p=<0.0001). Women who developed pre-eclampsia had significantly increased first-trimester augmentation index (1.13 vs 1.00 MoM, p<0.0001), pulse wave velocity, and central aortic systolic blood pressure.
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