Key result
Pregnancies delivering small for gestational age neonates with preeclampsia had increased aortic systolic blood pressure (1.09 vs 1.00 MoM) and augmentation index (1.13 vs 1.00 MoM) at 11-13 weeks compared to unaffected controls.
Population
6,814 pregnant women at 11+0 to 13+6 weeks' gestation, including those delivering small for gestational age…
Design
Cohort
Authors
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Early aortic SBP/AIx elevations may flag SGA with preeclampsia specifically; hypothesis-generating and should not yet change practice.
Observational (n=6,814)
Maternal hemodynamic alterations such as increased aortic systolic blood pressure and augmentation index at 11-13 weeks' gestation are specific to pregnancies delivering SGA neonates complicated by preeclampsia, rather than SGA alone.
Khalil et al. (2012) conducted an observational in Pregnancies delivering small for gestational age (SGA) neonates (n=6,814). Small for gestational age pregnancy with or without preeclampsia vs. Unaffected controls was evaluated on Aortic systolic blood pressure, pulse wave velocity, and augmentation index. Pregnancies delivering small for gestational age neonates with preeclampsia had increased aortic systolic blood pressure (1.09 vs 1.00 MoM) and augmentation index (1.13 vs 1.00 MoM) at 11-13 weeks compared to unaffected controls.
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