Key result
Compared to unaffected controls, women who developed pre-eclampsia had higher first-trimester AIx-75 (1.13 vs 1.00 MoM), PWV (1.06 vs 1.00 MoM), and central aortic systolic blood pressure (P<0.0001).
Why the study?
Do maternal hemodynamic parameters (SBPAo, PWV, AIx) at 11-13 weeks' gestation predict the development of pre-eclampsia?
Population
6,947 women with singleton pregnancies at 11 + 0 to 13 + 6 weeks' gestation
Comparison
Assessment of central aortic systolic blood… vs Unaffected controls
Design
Cohort
Follow-up
Until delivery (to assess development of pre-eclampsia)
Authors
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May support first-trimester hemodynamic screening for pre-eclampsia risk; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=6,947)
Do maternal hemodynamic parameters (SBPAo, PWV, AIx) at 11-13 weeks' gestation predict the development of pre-eclampsia?
Absolute Event Rate: 1.13% vs 1%
p-value: p=<0.0001
Increased central aortic systolic blood pressure and arterial stiffness are apparent in the first trimester of pregnancy among women who subsequently develop pre-eclampsia.
Khalil et al. (2012) conducted an observational in Pre-eclampsia (n=6,947). Subsequent development of pre-eclampsia vs. Unaffected controls was evaluated on AIx-75 (multiples of the median) (p=<0.0001). Compared to unaffected controls, women who developed pre-eclampsia had higher first-trimester AIx-75 (1.13 vs 1.00 MoM), PWV (1.06 vs 1.00 MoM), and central aortic systolic blood pressure (P<0.0001).
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