What question did this study set out to answer?

To determine whether arterial pulse wave analysis performed during the first trimester can predict the later development of pre-eclampsia.

December 12, 2008BJOG An International Journal of Obstetrics & Gynaecology

Pulse wave analysis: a preliminary study of a novel technique for the prediction of pre‐eclampsia

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Why the study?

Does first-trimester arterial pulse wave analysis predict pre-eclampsia in low-risk pregnant women?

Population

210 low-risk women with a singleton pregnancy

Design

Cohort

Follow-up

Until delivery (implied, to detect pre-eclampsia)

Authors

AKAA KhalilQueen Mary University of London DCD. J. CooperKing's College London KHK. HarringtonInstitute of Cancer Research

Discussion

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Implication

AIx-75 may aid early pre-eclampsia risk stratification in low-risk women; hypothesis-generating and should not change practice without validation.

Key Points

To determine whether arterial pulse wave analysis performed during the first trimester can predict the later development of pre-eclampsia.
Conducted a prospective screening study of 210 low-risk women with singleton pregnancies attending a single teaching hospital.
Measured radial artery pulse waveforms between 11(+0) and 13(+6) weeks of gestation to calculate aortic augmentation pressure and heart rate-adjusted augmentation index (AIx-75).
Modeled predictive performance using gestation-specific medians and logistic regression assessed by receiver operating characteristic curves.
Pre-eclampsia occurred in 14 of 210 women (6.7%), including 8 cases diagnosed before 34 weeks of gestation (early-onset), while 196 women remained normotensive.
At a fixed false-positive rate of 11%, AIx-75 achieved a detection rate of 79% for all pre-eclampsia cases and 88% for early-onset pre-eclampsia.

Structured PICO

Does first-trimester arterial pulse wave analysis predict pre-eclampsia in low-risk pregnant women?

Population

210 low-risk women with a singleton pregnancy

Intervention

First-trimester arterial pulse wave analysis (PWA) measuring radial artery pulse waveforms between 11(+0) and 13(+6) weeks of gestation to calculate augmentation index (AIx-75)

Outcome

Prediction of pre-eclampsia by AIx-75surrogate

First-trimester arterial pulse wave analysis (AIx-75) demonstrates promising predictive ability for the development of pre-eclampsia in low-risk pregnancies.

Cite This Study

Khalil et al. (2008) studied this question.

synapsesocial.com/papers/6a7e6b967ddcd43fa24f9cfb https://doi.org/10.1111/j.1471-0528.2008.01906.x

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Implication

AIx-75 may aid early pre-eclampsia risk stratification in low-risk women; hypothesis-generating and should not change practice without validation.

Pulse wave analysis: a preliminary study of a novel technique for the prediction of pre‐eclampsia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Pulse wave analysis: a preliminary study of a novel technique for the prediction of pre‐eclampsia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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