Key result
Women who subsequently developed gestational diabetes had significantly higher central aortic systolic blood pressure (1.03 vs 1.00 MoM; p<0.0001) at 11-13 weeks' gestation than non-GDM controls.
Why the study?
Do women who subsequently develop gestational diabetes mellitus have increased central aortic systolic blood pressure and arterial stiffness at 11-13 weeks' gestation compared to non-GDM controls?
Population
6,841 women with singleton pregnancies attending for routine antenatal care at 11-13 weeks' gestation.
Design
Cohort
Authors
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Early central aortic SBP elevation was associated with later GDM; hypothesis-generating for first-trimester screening, needs prospective validation.
Observational (n=6,841)
Do women who subsequently develop gestational diabetes mellitus have increased central aortic systolic blood pressure and arterial stiffness at 11-13 weeks' gestation compared to non-GDM controls?
Absolute Event Rate: 1.03% vs 1%
p-value: p=<0.0001
Increased central aortic systolic blood pressure and arterial stiffness are detectable in the first trimester of pregnancy before the clinical onset of gestational diabetes mellitus.
Khalil et al. (2012) conducted an observational in Gestational Diabetes Mellitus (n=6,841). Subsequent development of GDM vs. Non-GDM controls was evaluated on Central aortic systolic blood pressure (SBP(Ao)) (p=<0.0001). Women who subsequently developed gestational diabetes had significantly higher central aortic systolic blood pressure (1.03 vs 1.00 MoM; p<0.0001) at 11-13 weeks' gestation than non-GDM controls.
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