Key result
Increasing transvalvular pressure induced the greatest changes in porcine aortic valve fiber alignment between 0 and 1 mmHg, with no detectable change past 4 mmHg.
Population
Fresh porcine aortic valves
Design
Preclinical
Authors
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May inform low-pressure thresholds in bioprosthetic valve design; leaves open translation from porcine models to clinical performance.
The study demonstrates a complex, heterogeneous structural response of aortic valve fibers to transvalvular pressure, which may inform future bioprosthetic heart valve designs.
Sacks et al. (1998) studied this question. Transvalvular pressure was evaluated on Gross fiber structure and alignment. Increasing transvalvular pressure induced the greatest changes in porcine aortic valve fiber alignment between 0 and 1 mmHg, with no detectable change past 4 mmHg.
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