Key result
Increasing fixation pressure in porcine aortic valves was significantly associated with the absence of collagen crimp in cords and the mid-cusp region, whereas zero-pressure fixation preserved it.
Population
Porcine aortic valve (PAV) bioprostheses
Comparison
Zero-, low-, and high-pressure fixation vs Comparison among different fixation pressures
Design
Preclinical
Authors
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May inform optimized bioprosthetic fixation; leaves open translation to human durability and clinical outcomes.
Zero-pressure fixation of porcine aortic valves preserves collagen crimp across all cusp regions, which may have implications for improving the mechanical durability of bioprostheses.
Hilbert et al. (1990) studied this question. Fixation pressure (low and high) vs. Zero-pressure fixation was evaluated on Collagen crimp morphology and length. Increasing fixation pressure in porcine aortic valves was significantly associated with the absence of collagen crimp in cords and the mid-cusp region, whereas zero-pressure fixation preserved it.
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