Key result
Tethering and pressure-fixation of bovine pericardium during glutaraldehyde fixation controlled mechanical behavior, with tethering producing extensibility nearly identical to fresh tissue.
Why the study?
Does tethering or pressurization during fixation alter the tensile viscoelastic properties of bovine pericardium compared to simple fixation or fresh tissue?
Does tethering or pressurization during fixation alter the tensile viscoelastic properties of bovine pericardium compared to simple fixation or fresh tissue?
Tethering and pressure-fixation during glutaraldehyde treatment offer effective means to control the mechanical behavior of bovine pericardial xenograft materials.
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Tethered fixation may optimize pericardial xenografts for devices; leaves open translation to human implant durability.
Lee et al. (1989) studied this question. Tethering or pressurization during fixation vs. Simple fixation or fresh tissue was evaluated on Tensile viscoelastic properties (cyclic stress-strain response, stress relaxation, plastic deformation, fracture behavior). Tethering and pressure-fixation of bovine pericardium during glutaraldehyde fixation controlled mechanical behavior, with tethering producing extensibility nearly identical to fresh tissue.
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