Key result
Fixing bovine pericardium under uniaxial stress produces tensile anisotropy mimicking porcine aortic valve leaflets.
Population
Rectangular and cruciate bovine pericardial samples
Comparison
Fixation under uniaxial stress or sequential… vs Different stress treatments
Design
Preclinical
Authors
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Uniaxial stress fixation may enable anisotropic bovine pericardial leaflets; leaves open translation to durable clinical bioprostheses.
Uniaxial stress during fixation of bovine pericardium produces marked tensile anisotropy, which may be useful for constructing anisotropic heart valve leaflets.
Lee et al. (1989) studied this question. Uniaxial and sequential biaxial stress during fixation was evaluated on Tensile viscoelastic properties (response to cyclic loading, stress relaxation, plastic deformation, and fracture properties). Fixation of bovine pericardium under uniaxial stress produced marked tensile anisotropy similar to porcine aortic valve leaflets, which may be useful for constructing heart valve leaflets.
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