Key result
In experimental stress analysis of pericardial heterograft leaflets, restricted leaflet rotation and glutaraldehyde fixation under load increased compressive and total stresses, predisposing to fatigue.
Population
Bovine pericardium stabilized with glutaraldehyde used for heart valve substitutes
Design
Preclinical
Authors
Loading...
May warrant design caution in pericardial heterografts; leaves open optimal leaflet rotation and fixation parameters for durability studies.
Biomechanical stress analysis indicates that restricting leaflet rotation, fixing tissue under load, and using bicuspid designs increase compressive stresses in pericardial heterografts, potentially accelerating fatigue failure.
Trowbridge et al. (1987) studied this question. Pericardial heterograft leaflet design modifications was evaluated on Leaflet stresses (compressive and total stresses). In experimental stress analysis of pericardial heterograft leaflets, restricted leaflet rotation and glutaraldehyde fixation under load increased compressive and total stresses, predisposing to fatigue.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: