Why the study?
Increased leaflet mechanical stress is a primary determinant of bioprosthetic aortic valve structural deterioration, but differences between porcine and pericardial bioprostheses remained to be characterized.
Does a bioprosthesis with externally mounted pericardium have higher leaflet mechanical stress compared to an internally mounted porcine valve in an in vitro model?
Population
Mosaic and Trifecta surgical bioprostheses
Comparison
Bioprosthesis with externally mounted pericardium vs internally mounted porcine valve
Design
In vitro and in silico biomechanical study
Authors
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Hypothesis-generating for reduced pericardial valve durability; leaves open need for clinical validation.
Does a bioprosthesis with externally mounted pericardium have higher leaflet mechanical stress compared to an internally mounted porcine valve in an in vitro model?
In vitro and in silico modeling demonstrates that externally mounted pericardial bioprostheses experience higher maximum leaflet stress than internally mounted porcine valves, which may translate to shorter durability.
Stanová et al. (2021) studied this question.