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April 1, 1979ThoraxOpen Access

Influence of fixation conditions on the performance of glutaraldehyde-treated porcine aortic valves: towards a more scientific basis.

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Population

Glutaraldehyde-treated porcine aortic valves and commercially available Hancock valves

Comparison

Glutaraldehyde fixation at varying pressures vs Different fixation pressures

Design

Preclinical

Authors

NBNeil D. BroomFTFergus J. Thomson

Discussion

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Overview

Low-pressure fixation may preserve porcine valve microstructure; hypothesis-generating for bioprosthetic durability but requires clinical validation.

Structured PICO

P
Population
Glutaraldehyde-treated porcine aortic valves and commercially available Hancock valves
I
Intervention
Glutaraldehyde fixation at varying pressures (e.g., 100 mmHg, 4 mmHg, <1 mmHg)
C
Comparator
Different fixation pressures
O
Outcome
Collagen crimp geometry and mechanical stiffnesssurrogate

Fixing porcine aortic valves at very low pressures (<1 mmHg) preserves collagen crimp geometry and prevents strain localization, potentially improving long-term fatigue durability compared to higher pressures.

Cite This Study

Broom et al. (1979) studied this question.

synapsesocial.com/papers/6a9033b7bc81fe7dff4dcd22https://doi.org/10.1136/thx.34.2.166
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcification of glutaraldehyde-fixed porcine xenograft.1978 · 46 citations
  2. 2Seven Year Experience with Mounted Porcine Valves1977 · 25 citations