Key result
Monosodium glutamate postfixation of glutaraldehyde-fixed porcine aortic valves significantly reduced calcification at 90 days compared to glutaraldehyde alone (103.07 vs 199.33 µg/mg, p<0.01).
Why the study?
Does monosodium glutamate postfixation treatment reduce calcification in glutaraldehyde-fixed porcine aortic valves?
Population
36 pieces of fresh porcine aortic valves implanted subcutaneously into the backs of 18 rats
Comparison
Postfixation treatment with 1% monosodium… vs 0.625% glutaraldehyde fixation for 14 days…
Design
Preclinical
Follow-up
45 and 90 days
Authors
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Supports exploration of monosodium glutamate postfixation to mitigate bioprosthetic calcification; hypothesis-generating pending human studies.
Does monosodium glutamate postfixation treatment reduce calcification in glutaraldehyde-fixed porcine aortic valves?
Absolute Event Rate: 103.07% vs 199.33%
p-value: p=< 0.01
Monosodium glutamate postfixation of glutaraldehyde-fixed porcine aortic valves reduces calcification and preserves tissue collagen and water content in a rat subcutaneous model.
Liao et al. (1992) studied Bioprosthetic valve calcification (n=18). Monosodium glutamate postfixation vs. Glutaraldehyde fixation alone was evaluated on Tissue calcification (calcium content in micrograms/mg dry weight) at 90 days (p=< 0.01). Monosodium glutamate postfixation of glutaraldehyde-fixed porcine aortic valves significantly reduced calcification at 90 days compared to glutaraldehyde alone (103.07 vs 199.33 µg/mg, p<0.01).