Why the study?
Does preservation with glutaraldehyde alter the mechanical properties of human femoral vein walls and valve cusps?
Does preservation with glutaraldehyde alter the mechanical properties of human femoral vein walls and valve cusps?
Glutaraldehyde preservation does not alter the mechanical properties of human femoral vein valves, supporting its potential use for implanting preserved vein valves in post-phlebitic syndrome.
Glutaraldehyde preservation maintains mechanics in this model; leaves open whether preserved valves warrant trials in post-phlebitic syndrome.
In the hope that some varieties of the post-phlebitic syndrome might be treated by implanting a preserved vein valve, studies have been made of the mechanical properties of vein valves and vein wall before and after preservation with glutaraldehyde. The ultimate tensile strength (breaking stress) and strain (extensibility) of strips of vein wall and valve leaflet were measured with a Nene tensiometer. The ultimate tensile strength of valve leaflet was found to be twice that of vein wall. Preservation in glutaraldehyde (0.2 per cent, pH 7.4, for 7 days) with valve cusps closed by a minimum head of pressure caused no change in breaking stress or extensibility.
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Ackroyd et al. (1985) studied this question.
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