Why the study?
Polymeric heart valves aim to combine the hemodynamics of biological and the longevity of mechanical prostheses, motivating structural modifications to improve performance of the PIZZA transcatheter valve prototype.
Structural modifications to a polymeric transcatheter valve prototype significantly improved its hemodynamic performance in vitro, representing a step toward an easily producible nonbiological transcatheter valve.
BACKGROUND: Polymeric heart valves are constructed from flexible synthetic materials, therefore aiming to combine the advantageous hemodynamic of biological and the longevity of mechanical valve prostheses. One such valve prototype in development is the PIZZA valve constructed of flexible triangular silicone leaflets on a foldable metal base for perspective transcatheter implantation. Here we present further improvements in its performance through structural modifications. METHODS: Structurally modified prototypes were constructed from silicone sheets and stainless-steel wires. Their performance was then tested in a hemodynamic testing device of the type HKP 2.0. RESULTS: Shift from a planar to a cone shape as well as overlapping of the leaflets significantly improved the valves performance, reducing regurgitation as well as systolic pressure gradients. CONCLUSIONS: The results of the modified prototypes expressed superior performance and represented a step forward on the road to an easily producible, polymeric transcatheter valvular prosthesis.
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Schröter et al. (2019) studied this question. Structurally modified PIZZA valve prototypes (cone shape and overlapping leaflets) vs. Planar shape prototypes was evaluated on Hemodynamic performance (regurgitation and systolic pressure gradients).
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