Key result
HLA-DR4 frequency was significantly higher in patients with dilated cardiomyopathy compared to regional controls (21.25% vs 10.73%; RR 2.30; p=0.02), with no association found with cardiac antibodies.
Why the study?
Is there an association between HLA-DR antigens and the presence of organ-specific cardiac antibodies in patients with idiopathic dilated cardiomyopathy?
Population
80 Caucasian patients with idiopathic dilated cardiomyopathy from Northern Italy, and 289 healthy blood…
Design
Case-control
Authors
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HLA-DR4 was associated with dilated cardiomyopathy susceptibility; leaves open any mechanistic link to cardiac autoantibodies or clinical utility.
Case-Control (n=369)
Is there an association between HLA-DR antigens and the presence of organ-specific cardiac antibodies in patients with idiopathic dilated cardiomyopathy?
Relative Risk: 2.3
Absolute Event Rate: 21.25% vs 10.73%
p-value: p=0.02
While HLA-DR4 is associated with susceptibility to dilated cardiomyopathy, it does not appear to be associated with the production of organ-specific cardiac autoantibodies.
Caforio et al. (1992) conducted a case-control in Idiopathic dilated cardiomyopathy (n=369). HLA-DR4 antigen vs. Healthy blood donors was evaluated on HLA-DR4 frequency (RR 2.30, p=0.02). HLA-DR4 frequency was significantly higher in patients with dilated cardiomyopathy compared to regional controls (21.25% vs 10.73%; RR 2.30; p=0.02), with no association found with cardiac antibodies.
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