Why the study?
Do T-lymphocytes from patients with Chagas' disease mediate cytotoxicity against human heart cells?
Population
T-lymphocytes from 11 human donors tested against 51Cr-labelled primary human fetal heart cell cultures.
Comparison
T-lymphocytes from patients with acute or… vs T-lymphocytes from normal, non-chagasic donors
Design
Preclinical
Authors
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In vitro T-cell cytotoxicity against heart cells in Chagas disease is hypothesis-generating; leaves open autoimmune mechanisms for clinical cardiomyopathy.
Do T-lymphocytes from patients with Chagas' disease mediate cytotoxicity against human heart cells?
This in vitro study demonstrates that T-lymphocytes from patients with Chagas' disease destroy human heart cells, suggesting an autoimmune mechanism mediated by delayed-type hypersensitivity in the pathogenesis of Chagas cardiomyopathy.
Teixeira et al. (1978) studied this question.
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