Key result
Factor V Leiden mutation was significantly associated with stillbirth among 5,000 pregnant women, confirming the link between genetic thrombophilia and selected obstetric complications.
Why the study?
Does the presence of Factor V Leiden or prothrombin G20210A mutations increase the risk of obstetric complications in pregnant women?
Population
5,000 pregnant women
Comparison
Presence of Factor V Leiden or prothrombin… vs Absence of FVL or PT G20210A mutations
Design
Cohort
Authors
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Should not yet alter screening or management; extends observational data but requires randomized confirmation.
Observational (n=5,000)
Does the presence of Factor V Leiden or prothrombin G20210A mutations increase the risk of obstetric complications in pregnant women?
Factor V Leiden mutation is significantly associated with stillbirth, confirming the link between genetic thrombophilia and selected obstetric complications.
Kocher et al. (2007) conducted an observational in Pregnancy (n=5,000). Factor V Leiden (FVL) and prothrombin (PT) G20210A mutations vs. Absence of mutations was evaluated on Obstetric complications including stillbirth, placental abruption, intrauterine growth retardation, preterm delivery, miscarriage, and preeclampsia. Factor V Leiden mutation was significantly associated with stillbirth among 5,000 pregnant women, confirming the link between genetic thrombophilia and selected obstetric complications.
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