Key result
Mobilization of stem/progenitor cells expressing chemokine receptors correlates with improved left ventricular ejection fraction and remodeling at 1-year follow-up after acute myocardial infarction.
Chemokine-mediated mobilization of stem/progenitor cells after acute myocardial infarction correlates with improved left ventricular ejection fraction, remodeling, and myocardial perfusion.
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Should not yet change post-MI care; hypothesis-generating for chemokine-mediated stem cell mobilization as a therapeutic target.
Wojakowski et al. (2008) conducted a review in Acute myocardial infarction. Chemokine signalling (CXCR4/SDF-1, CD117/SCF, c-met/HGF) was evaluated. Mobilization of stem/progenitor cells expressing chemokine receptors correlates with improved left ventricular ejection fraction and remodeling at 1-year follow-up after acute myocardial infarction.
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