Aztreonam, the First Monobactam

Editorials1 May 1987Aztreonam, the First MonobactamRICHARD J. DUMA, M.D., Ph.D.RICHARD J. DUMA, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-106-5-766 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince Fleming's Discovery of penicillin almost 50 years ago (2), several closely related types of beta lactams have emerged, each with minor chemical alterations in structures attached to the nucleus that produce profound changes in the biologic properties of the molecule. Chemically, all beta lactams have two characteristics in common: they have bioactive beta lactam rings and they are fused bicyclic compounds. However, now a new and very different class of beta lactams, the monobactams, is entering the antibiotic arena. Although they still have the beta lactam ring, the monobactams are not fused bicyclic compounds.Monobactams are naturally occurring, and,...References1. BERGER S. Apocalypse [Letter]. N Engl J Med. 1985;312:1394-5. CrossrefMedlineGoogle Scholar2. FLEMING A. On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae. Br J Exp Pathol. 1929;10:226-36. Google Scholar3. SYKES R, CIMARUSTI C, and BONNER D. Monocyclic beta-lactam antibiotics produced by bacteria. Nature. 1981;291:489-91. CrossrefMedlineGoogle Scholar4. BREUER H, CIMARUSTI T, DENZEL T, KOSTER W, SLUSARCHYK W, and TREUNER U. Monobactams—structure-activity relationships leading to SQ 26,776. J Antimicrob Chemother. 1981;8(suppl E):21-8. CrossrefMedlineGoogle Scholar5. NEU H and LABTHAVIKUL P. Antibacterial activity of a monocyclic beta-lactam SQ 26,776. J Antimicrob Chemother. 1981;8(suppl E):111-22. CrossrefMedlineGoogle Scholar6. SYKES R and BONNER D. 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DUMA, M.D., Ph.D.Affiliations: Medical College of Virginia Division of Infectious Diseases Richmond, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResistance to Antimicrobial Agents: From Bacteria to YeastChromobacterium violaceum: A Review of an Unexpected ScourgeCopper‐Catalyzed Oxidative Benzylic C(sp 3 )−H Cyclization for the Synthesis of β‐LactamsAntibacterial and β-Lactamase Inhibitory Activity of Monocyclic β-LactamsIodine(III)-Catalyzed Cascade Reactions Enabling a Direct Access to β-Lactams and α-Hydroxy-β-amino AcidsCH Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen-Containing HeterocyclesChromobacterium violaceum Septicaemia and Urinary Tract Infection: Case Reports from a Tertiary Care Hospital in South IndiaOther Gram-Negative and Gram-Variable BacilliAccess to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp 3 )H AlkylationAccess to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp 3 )H AlkylationData-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and DiscoveryNonpigmented Chromobacterium violaceum bacteremic cellulitis after fish biteOther Gram-Negative and Gram-Variable BacilliMISCELLANEOUS NON-ENTEROBACTERIACEAE FERMENTATIVE BACILLINon-chromogenic chromobacterium violaceum bacteremiaNear‐fatal septicaemia with Chromobacterium violaceum 1 May 1987Volume 106, Issue 5Page: 766-767KeywordsAntibioticsBiologicsPenicillin ePublished: 1 December 2008 Issue Published: 1 May 1987 PDF downloadLoading ...