Population
In vitro pulsatile mock circulatory system and calves (n=51 pump implantations)
Design
Preclinical
Follow-up
up to 316 days
Authors
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May implicate mechanical stress in bioprosthetic calcification; extends animal data but leaves open human durability implications.
Human dura mater valves implanted in calves undergo collagen degeneration and calcification in areas under mechanical stress, highlighting the role of mechanical damage in valve calcification.
Harasaki et al. (1979) studied this question.
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