Key result
Weight loss over 3 months in obese patients improved left ventricular diastolic function and enhanced right ventricular function as assessed by conventional and tissue Doppler echocardiography.
Why the study?
Does weight loss improve left and right ventricular functions in obese patients?
Observational (n=30)
Does weight loss improve left and right ventricular functions in obese patients?
Weight loss in obese patients is associated with reversible improvements in both left and right ventricular systolic and diastolic functions as assessed by tissue Doppler echocardiography.
May support reversible biventricular gains with weight loss in obesity; hypothesis-generating and requires RCTs before practice change.
OBJECTIVE: In our study, we aimed to evaluate the effect of weight loss on left and right ventricular functions in obese patients. METHODS: Thirty patients with a BMI greater than 30 kg/m(2) and without any exclusion criteria were included in the study. Left ventricular systolic and diastolic functions were assessed with conventional and tissue Doppler echocardiography (TDE). At the end of 3 months, echocardiographic examination was repeated in patients with weight loss for cardiac function evaluation and it was compared to the baseline echocardiographic parameters. RESULTS: At the end of 3 months of weight loss period, conventional Doppler echocardiography revealed an improvement in diastolic functions with an increase in mitral E-wave, a decrease in mitral A-wave and an increase in E/A ratio. Deceleration time and isovolumetric relaxation time were ascertained shortened and Tei index decreased. TDE showed an increase in left ventricular lateral wall systolic wave (Sm) and E-wave velocity (Em). Mitral septal annular isovolumetric acceleration time (IVA), Sm and Em, were found to be increased, whereas Tei index was ascertained reduced. Right ventricular tissue Doppler examination following weight loss revealed an increase in RV- IVA, RV-Sm, and RV-Em, and a decrease in Tei index. CONCLUSION: We disclosed that left ventricular structural changes and diastolic dysfunction occur in obese patients, and by weight loss, these abnormalities may be reversible which we demonstrated both by conventional and TDE. In addition, obesity might impair RV function as well, and we observed an enhancement in right ventricular functions by weight loss.
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Yüksel et al. (2016) conducted an observational in Obesity (n=30). Weight loss vs. Baseline was evaluated on Left and right ventricular functions. Weight loss over 3 months in obese patients improved left ventricular diastolic function and enhanced right ventricular function as assessed by conventional and tissue Doppler echocardiography.
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