Key result
Overweight and obesity independently increased the risk of left ventricular diastolic dysfunction by 2.13 times and 3.10 times, respectively, compared to normal weight individuals.
Why the study?
Does overweight and obesity worsen left ventricular diastolic function in patients with normal systolic function?
Cross-Sectional (n=2,684)
No
Does overweight and obesity worsen left ventricular diastolic function in patients with normal systolic function?
Diastolic function worsens with increasing weight before the development of systolic dysfunction, and tissue Doppler imaging is sensitive for detecting these early changes in overweight and obese patients.
Answers are grounded in this paper and cite their sources.
May warrant closer diastolic monitoring in overweight patients with preserved EF; extends observational data but leaves causality open.
Background and Objectives: Obesity is a cause of cardiac dysfunction.We analyzed the change of diastolic function with the increase of the body mass index (BMI) for the early detection of cardiac dysfunction in overweight and obese patients.To analyze the diastolic function, we measured the mitral valve early and late diastolic inflow velocities with performing Doppler studies (E, A) and the early and late mitral annulus velocities with performing tissue Doppler studies (E', A').Subjects and Methods: From January 2005 to October 2007, 2,684 cases were enrolled in this study.The patients had a normal cardiac size, normal systolic function, no regional wall motion abnormalities and no significant valve disease.Those patients with a history of congenital heart disease, renal failure and congestive heart failure were excluded.The BMI was checked and Doppler echocardiographic analysis, including tissue Doppler, was done.Results: The left ventricle (LV) mass index (normal : 89.1±19.1,overweight: 95.7±18.4,obese: 97.2±18.9g/m 2 , p<0.01), and the E/E' (8.84±2.81,10.02±3.03,10.84±3.66,respectively, p<0.01) were higher, and the E (72.4±16.7,68.6±16.0,71.5±17.0cm/sec, respectively, p<0.01), and E' (8.78±2.77,7.27±2.19,7.17±2.62cm/sec, respectively, p<0.01) were lower in the overweight (BMI≥25 kg/m 2 ) and obese groups (BMI≥30 kg/m 2 ) than that of the normal group.On multiple logistic regression analysis, overweight was an independent risk factor for diastolic dysfunction with considering other risk factors such as hypertension, diabetes mellitus, age and gender.The risk of LV diastolic dysfunction was increased 2.13 times in the overweight group and 3.1 times in the obese group as compared with the normal group.Conclusion: With an increase of weight, diastolic function was worsened before the development of systolic dysfunction.This change was apparent in the overweight group.Tissue Doppler study on the mitral annulus is more sensitive to detect the change of diastolic function in overweight and obese patients.(Korean Circ J 2008;38:270-275)
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Ryu et al. (2008) conducted a cross-sectional in Overweight and Obesity (n=2,684). Overweight (BMI 25-29.9 kg/m²) vs. Normal weight (BMI <25 kg/m²) was evaluated on Left ventricular diastolic dysfunction (OR 2.13, 95% CI 1.76-2.63, p=<0.01). Overweight and obesity independently increased the risk of left ventricular diastolic dysfunction by 2.13 times and 3.10 times, respectively, compared to normal weight individuals.
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