Key result
Overweight and obesity independently increased the risk of left ventricular diastolic dysfunction by 2.13 times and 3.10 times, respectively, compared to normal weight individuals.
Why the study?
Does overweight and obesity worsen left ventricular diastolic function in patients with normal systolic function?
Population
2,684 patients aged 18-55 years with normal cardiac size, normal systolic function, no regional wall motion…
Comparison
Overweight and Obesity vs Normal weight (BMI <25 kg/m²)
Design
Cross-sectional
Authors
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May warrant closer diastolic monitoring in overweight patients with preserved EF; extends observational data but leaves causality open.
Cross-Sectional (n=2,684)
No
Does overweight and obesity worsen left ventricular diastolic function in patients with normal systolic function?
Odds Ratio: 2.13 (95% CI 1.76–2.63)
p-value: p=<0.01
Diastolic function worsens with increasing weight before the development of systolic dysfunction, and tissue Doppler imaging is sensitive for detecting these early changes in overweight and obese patients.
Ryu et al. (2008) conducted a cross-sectional in Overweight and Obesity (n=2,684). Overweight (BMI 25-29.9 kg/m²) vs. Normal weight (BMI <25 kg/m²) was evaluated on Left ventricular diastolic dysfunction (OR 2.13, 95% CI 1.76-2.63, p=<0.01). Overweight and obesity independently increased the risk of left ventricular diastolic dysfunction by 2.13 times and 3.10 times, respectively, compared to normal weight individuals.
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