Key result
Immunization with dendritic cells expressing human PrP significantly prolonged mean survival time from 209 days in untreated mice to 246 days in mice infected with experimental scrapie.
Population
Wild-type C57BL/6 mice, Prnp-/- mice, and Tg650 mice (overexpressing hPrP) challenged with 139A scrapie.
Comparison
Immunization with adenovirus encoding human PrP… vs Untreated mice or mice immunized with control Ad.
Design
Preclinical
Follow-up
up to 300 days
Authors
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Hypothesis-generating for prion immunotherapy; leaves open translation of DC-based PrP immunization to human disease.
Effect estimate: 37 days prolongation
Absolute Event Rate: 246% vs 209%
p-value: p=0.0003
Dendritic cell-mediated immunization with xenogenic PrP breaks immune tolerance and significantly prolongs survival in a mouse model of scrapie.
Rosset et al. (2009) studied Experimental Scrapie (Prion Disease). Dendritic cell-mediated immunization with xenogenic PrP (DCTg650AdTA) vs. Untreated or control adenovirus (AdTA) was evaluated on Mean survival time (days post infection) (37 days prolongation, p=0.0003). Immunization with dendritic cells expressing human PrP significantly prolonged mean survival time from 209 days in untreated mice to 246 days in mice infected with experimental scrapie.
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