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September 1, 2012PrionOpen Access

Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice

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Why the study?

Does brain delivery of AAV9 expressing scFvD18 delay prion disease in scrapie-infected mice?

Population

Mice infected by intraperitoneal route with the mouse-adapted scrapie strain RML

Design

Preclinical

Authors

FMFabio ModaCVChiara VimercatiICIlaria Campagnani

Discussion

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Overview

Supports AAV9-scFvD18 development in prion models; leaves open human translation.

Structured PICO

Does brain delivery of AAV9 expressing scFvD18 delay prion disease in scrapie-infected mice?

P
Population
Mice infected by intraperitoneal route with the mouse-adapted scrapie strain RML
I
Intervention
Recombinant Adeno-Associated Viral vector serotype 9 (AAV9) delivering single chain variable fragment D18 antibody (scFvD18) to the brain
O
Outcome
Incubation time of scrapie-infected animals and burden of total proteinase-resistant PrP(Sc) in the brainsurrogate

In vivo delivery of an anti-PrP antibody via AAV9 vector delays prion disease progression and reduces misfolded protein burden in a mouse model.

Cite This Study

Moda et al. (2012) studied this question.

synapsesocial.com/papers/6a81614fadfa6baaaee1d0bchttps://doi.org/10.4161/pri.20197
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