The Effect of Haemodilution on Antithrombin Concentration during Cardiac Surgery
Key result
Cardiopulmonary bypass during cardiac surgery decreased antithrombin concentration to 52% of baseline (vs 82% without bypass), which correlated with haemodilution (r=0.76).
Why the study?
Does cardiopulmonary bypass affect antithrombin concentration during elective cardiac surgery?
Population
73 patients undergoing elective cardiac surgery
Comparison
Cardiopulmonary bypass vs No cardiopulmonary bypass
Design
Cohort
Follow-up
during surgery
Authors
Discussion
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Member takes
Implication
Bypass during cardiac surgery is associated with greater antithrombin reduction due to haemodilution; leaves open whether correction affects outcomes.
Study Design
Type
Observational (n=73)
Structured PICO
Does cardiopulmonary bypass affect antithrombin concentration during elective cardiac surgery?
P
Population
73 patients undergoing elective cardiac surgery with and without cardiopulmonary bypass.
E
Exposure
Cardiopulmonary bypass
C
Comparator
No cardiopulmonary bypass
O
Outcome
Change in antithrombin concentration during surgerysurrogate
Main Result
Effect estimate: r 0.76
Absolute Event Rate: 52% vs 82%
The percentage decrease in haemoglobin concentration can be used to estimate the percentage decrease in antithrombin concentration during cardiac surgery.
Limitations
- Administration of blood products between measurements might affect the results
Cite This Study
Linden et al. (2004) conducted an observational in Elective cardiac surgery (n=73). Cardiopulmonary bypass vs. Without cardiopulmonary bypass was evaluated on Antithrombin concentration as a percentage of baseline (r 0.76). Cardiopulmonary bypass during cardiac surgery decreased antithrombin concentration to 52% of baseline (vs 82% without bypass), which correlated with haemodilution (r=0.76).