Key result
Preoperative ADP receptor antagonist alone increased 24-hour postoperative blood loss compared to no treatment or combined ADP antagonist plus heparin (633 vs 503 vs 439 mL, P<0.05).
Why the study?
Does preoperative treatment with platelet ADP receptor antagonists with or without IV heparin influence postoperative blood loss in adults undergoing coronary artery bypass graft surgery?
Population
93 adult subjects undergoing coronary artery bypass graft surgery
Comparison
Preoperative treatment with platelet adenosine… vs No preoperative treatment within the week before…
Design
Cohort
Follow-up
24 hours
Authors
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May warrant bleeding caution with preoperative ADP antagonists alone in CABG; leaves open heparin mitigation pending randomized confirmation.
Cohort (n=93)
Does preoperative treatment with platelet ADP receptor antagonists with or without IV heparin influence postoperative blood loss in adults undergoing coronary artery bypass graft surgery?
Absolute Event Rate: 633% vs 503%
p-value: p=< 0.05
Preoperative use of ADP receptor antagonists alone increases postoperative blood loss after CABG, but this effect appears to be mitigated by the addition of a heparin infusion.
Pothula et al. (2004) conducted a cohort in Coronary artery bypass graft surgery (n=93). Preoperative platelet ADP receptor antagonist vs. No preoperative treatment or ADP receptor antagonist plus IV heparin was evaluated on Postoperative chest tube drainage at 24 hours (p=< 0.05). Preoperative ADP receptor antagonist alone increased 24-hour postoperative blood loss compared to no treatment or combined ADP antagonist plus heparin (633 vs 503 vs 439 mL, P<0.05).
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