Key result
Heparin and protamine both prolonged platelet hemostasis time and collagen-induced thrombus formation, with protamine reversal of heparin's antiplatelet effect occurring within a narrow window.
Why the study?
Do heparin, protamine, and varying heparin/protamine ratios affect platelet function under conditions of arterial shear stress in an in vitro model?
Population
In vitro physiologic model using flowing whole blood
Design
Preclinical
Authors
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Protamine reversal of heparin's antiplatelet effect occurs within a narrow window (optimal at a 1:1.5 ratio) due to the direct antiplatelet effects of protamine.
Do heparin, protamine, and varying heparin/protamine ratios affect platelet function under conditions of arterial shear stress in an in vitro model?
Protamine reversal of heparin's antiplatelet effect occurs within a narrow window (optimal at a 1:1.5 ratio) due to the direct antiplatelet effects of protamine.
Griffin et al. (2001) studied Blood loss after cardiopulmonary bypass. Heparin, protamine, and heparin/protamine ratios was evaluated on Platelet hemostasis time (PHT) and collagen-induced thrombus formation (CITF). Heparin and protamine both prolonged platelet hemostasis time and collagen-induced thrombus formation, with protamine reversal of heparin's antiplatelet effect occurring within a narrow window.
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