Key result
Protamine titration using the Hemochron system significantly reduced the required protamine dose compared with an empirical dose protocol (p<0.01) while maintaining adequate heparin reversal.
Why the study?
Does protamine titration using the Hemochron system reduce the required protamine dose compared to an empirical dose protocol in patients undergoing elective myocardial revascularisation?
Does protamine titration using the Hemochron system reduce the required protamine dose compared to an empirical dose protocol in patients undergoing elective myocardial revascularisation?
p-value: p=<0.01
Protamine titration using the Hemochron system significantly reduces the required protamine dose for heparin reversal after cardiopulmonary bypass compared to an empirical protocol, while maintaining adequate reversal.
May support titration-guided protamine dosing to limit exposure in CABG; hypothesis-generating and requires randomized confirmation before practice change.
A simple method of protamine titration using the Hemochron system was compared with an empirical dose protocol for reversal of heparinisation following cardiopulmonary bypass in 40 patients undergoing elective myocardial revascularisation. Protamine titration revealed a wide range for protamine requirement and resulted in a significant reduction in protamine dose compared with the empirical dose protocol (p less than 0.01). Heparin reversal was assessed as adequate in all patients. The titration technique was easy and straightforward to use in the operating theatre.
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Keeler et al. (1991) studied elective myocardial revascularisation (n=40). Protamine titration using the Hemochron system vs. empirical dose protocol was evaluated on protamine dose (p=<0.01). Protamine titration using the Hemochron system significantly reduced the required protamine dose compared with an empirical dose protocol (p<0.01) while maintaining adequate heparin reversal.
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